Sickle cell anemia as an inflammatory disease
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چکیده
منابع مشابه
Sickle cell anemia as an inflammatory disease.
The classical view of sickle cell anemia has always focused on the primary genetic defect — the abnormal sickle hemoglobin that polymerizes when deoxygenated. Polymerization within the red cell causes it to deform, to become rigid, to obstruct blood flow, and to produce acute and chronic tissue damage because of poor perfusion. A more holistic view sees the sickle red cell with its abnormal con...
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Sickle cell anemia (SCA) is a chronic haemoglobinopathy that can affect many organs in the body including gastrointestinal tract. However, colonic involvement is very rare and usually in the form of ischemic colitis. We are reporting an 11-year-old Saudi girl with SCA who presented with persistent diarrhea and was found to have inflammaftory bowel disease.
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s of Papers Presented at the 1949Philadelphia, Pennsylvania Historical Botanical Collections of the American Philosophical Society and the Academy ofNatural Sciences of Philadelphia
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Background: Hemoglobin S arises is the result of a point mutation (A-T) in the sixth codon on the -globin gene on chromosome 11 causing sickle cell anemia. The presence of fetal hemoglobin in infancy plays a relatively protective role for vaso-occlusive symptoms that are the major contributor for the morbidity and mortality among patients with sickle cell anemia. hydroxyurea, an s-phase-specif...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2000
ISSN: 0021-9738
DOI: 10.1172/jci10726